ScholarWorks@Sookmyung Women's University
http://scholarworks.sookmyung.ac.kr:80
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2024-03-19T08:39:34Z
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Endothelial periostin regulates vascular remodeling by promoting endothelial dysfunction in pulmonary arterial hypertension
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159610
Title: Endothelial periostin regulates vascular remodeling by promoting endothelial dysfunction in pulmonary arterial hypertension
Authors: Lee, Dawn; Lee, Heeyoung; Jo, Ha-neul; Yun, Eunsik; Kwon, Byung Su; Kim, Jongmin; Lee, Aram
Abstract: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with extracellular matrix (ECM) deposition, vascular cell hyperproliferation, and neointima formation in the small pulmonary artery. Endothelial dysfunction is considered a key feature in the initiation of vascular remodeling. Although vasodilators have been used for the treatment of PAH, it remains a life-threatening disease. Therefore, it is necessary to identify novel therapeutic targets for PAH treatment. Periostin (POSTN) is a secretory ECM protein involved in physiological and pathological processes, such as tissue remodeling, cell adhesion, migration, and proliferation. Although POSTN has been proposed as a potential target for PAH treatment, its role in endothelial cells has not been fully elucidated. Here, we demonstrated that POSTN upregulation correlates with PAH by analyzing a public microarray conducted on the lung tissues of patients with PAH and biological experimental results from in vivo and in vitro models. Moreover, POSTN overexpression leads to ECM deposition and endothelial abnormalities such as migration. We found that PAH-associated endothelial dysfunction is mediated at least in part by the interaction between POSTN and integrin-linked protein kinase (ILK), followed by activation of nuclear factor-kappa B signaling. Silencing POSTN or ILK decreases PAH-related stimuli-induced ECM accumulation and attenuates endothelial abnormalities. In conclusion, our study suggests that POSTN serves as a critical regulator of PAH by regulating vascular remodeling, and targeting its role as a potential therapeutic strategy for PAH.
2024-12-01T00:00:00Z
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DewMetrics: Demystification of the Dew Computing in Sustainable Internet of Things
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159613
Title: DewMetrics: Demystification of the Dew Computing in Sustainable Internet of Things
Authors: Roy, S.; Panda, D.; Kim, B.-G.; Bairagi, P.; Mondal, T.; Arosh, S.; Sinha, S.; De, D.; Wang, Y.; Skala, K.; Davidovic, D.
Abstract: Dew computing, a new version of the computing paradigm appeared along with cloud, edge, and fog computing. Dew computing is a distributed computing framework that is deliberated as an augmentation in the cloud computing schema. Researchers and academic practitioners have explored the concept of dew computing since its germination. In dew computing, users can perform full system functionality without depending on Internet availability. Information will be warehoused on the local storage of the user’s device, and when the Internet connection is present, harmonization will be accomplished to synchronize the transmitted information on cloud-dependent applications. There have been voluminous implementations of dew computing in prevailing usages, although research achieved concerning dew computing is not as much as in erstwhile distributed computing spheres. They have even tried to integrate computing into several existing and sustainable applications, such as the Internet of Things, smart Healthcare, Indoor navigation, agriculture, and numerous human-centric paradigms. The key objective of dew computing is to enhance the efficiency and reduce the cost of personal IoT devices which further augment the productivity and scalability of any distributed computing network. In this chapter, we first briefly focus on unfolding the concept of dew computing. We illustrate a set of real-time case studies, such as the cache computing framework for dew devices, the reduced Internet dependency-induced decision-making processes, the crises, the humanitarian Internet of Music Things, and so on, where the flow of information should be abundant despite having issues with constant digital network connectivity. We would focus on providing a detailed literature survey of dew computing architecture, applications, tools, and technologies that might assist in delivering ICT-based sustainable Internet of Things applications. This chapter additionally provides a deep insight into upcoming tools and technologies that can be integrated with the conventional dew computing architecture for obtaining more efficiency in Internet-dependent distributed networks.
2024-09-01T00:00:00Z
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A Time-Based Direct MPPT Technique for Low-Power Photovoltaic Energy Harvesting
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159596
Title: A Time-Based Direct MPPT Technique for Low-Power Photovoltaic Energy Harvesting
Authors: Maeng, J.; Jeong, J.; Park, I.; Shim, M.; Kim, C.
Abstract: This letter introduces a maximum power point tracking (MPPT) technique for photovoltaic (PV) energy harvesting (EH) systems to enhance the end-to-end efficiency (ηE-E) when the output power of PV cell (PPV,MAX) is low. A ripple-based PV cell current sensing and a time domain multiplication are proposed to monitor the PV cell power delivered to the charger, which reduces the controller power consumption (PCTR). The PV EH system with the proposed MPPT method is implemented in a 180-nm CMOS process. The PCTR is 1.34 μW. The measured ηE-E at low PPV,MAX (13 μW) is 88%. The measured peak ηE-E is 94.4% at 82 μW. IEEE
2024-05-01T00:00:00Z
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Assessing the impact of climate and air quality policies on future emissions in Korea through quantification of control and co-control effects
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/159437
Title: Assessing the impact of climate and air quality policies on future emissions in Korea through quantification of control and co-control effects
Authors: Jang, Y.; Hu, H.; Kim, B.; Kim, Y.; Yoo, S.-J.; Jang, K.; Kim, Y.-K.; Jin, H.; Woo, J.-H.
Abstract: Climate policies designed to reduce greenhouse gas (GHG) emissions can also lead to reduced air pollutants, and conversely, air pollution reduction policies can contribute to GHG reductions. We defined “control” as achieving key policy goals and “co-control” as achieving additional goals simultaneously. This study quantitatively analyzed the effects of Korea's Climate and air pollutant reduction policies using the GHGs and air pollutant Unified Information Design system for Environment (GUIDE) model, which facilitates an integrated analysis of the control and co-control effects of these policies. We incorporated the latest policies in Korea into the model and developed four scenarios to generate and evaluate future emission inventories for each scenario until 2030. The four scenarios include the baseline scenario (no additional policy), the Nationally Determined Contribution (NDC) scenario (climate policies), the Air Quality Management (AQM) scenario (air quality policies), and the NDC+AQM scenario (both policies). The analysis results from the NDC and the NDC+AQM scenarios present the reduction effects of CO2 emissions due to climate policies and illustrate the co-control effects that reduce atmospheric pollutants such as SOx, NOx, and PM2.5 as well. Moreover, through a comparative analysis of emission reduction outcomes across the four scenarios, this study shows the advantages of concurrently evaluating climate and air quality policies using the integrated model. Furthermore, by assessing the effects of policies within each emission sector, we can identify sections necessitating supplementary reduction strategies. The findings presented in this research offer valuable insights and data to inform forthcoming policy development and assessment endeavors. © 2023 Turkish National Committee for Air Pollution Research and Control
2024-01-01T00:00:00Z