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Implantable Cisplatin Synthesis Microdevice for Regional Chemotherapy

Authors
Campbell, RebeccaShim, HyunjiChoi, JePark, MoonchulByun, EunjeongIslam, SayemulSong, Seung HyunKim, Albert
Issue Date
Feb-2021
Publisher
WILEY
Keywords
cancer; cisplatin; implantable microdevices; regional chemotherapy
Citation
ADVANCED HEALTHCARE MATERIALS, v.10, no.3, pp 1 - 7
Pages
7
Journal Title
ADVANCED HEALTHCARE MATERIALS
Volume
10
Number
3
Start Page
1
End Page
7
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1007
DOI
10.1002/adhm.202001582
ISSN
2192-2640
2192-2659
Abstract
Cisplatin, the first platinum chemotherapy agent to obtain Food and Drug Administration (FDA) approval in 1978, is widely used for a number of cancers. However, the painful side effects stemming from systemic delivery are the inevitable limitation of cisplatin. A possible solution is regional chemotherapy using various drug delivery systems, which reduces the systemic toxicity and increases drug accumulation in the tumor. In this paper, a rice-grain sized, ultrasonically powered, and implantable microdevice that can synthesize cisplatin in situ is presented. The microdevice produces 0.7 mg of cisplatin within 1 h under ultrasonic irradiation (400 mW cm(-2)). The effect of the microdevice-synthesized cisplatin is evaluated using in vitro murine breast cancer cells and ex vivo liver tissue. The results suggest that cytotoxic activities of the microdevice-mediated cisplatin delivery are significantly higher in both in vitro and ex vivo experiments. Overall, the proposed cisplatin synthesis microdevice represents a strong alternative treatment option for regional chemotherapy
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첨단소재·전자융합공학부 (지능형전자시스템전공)
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