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IL-18 and Cutaneous Inflammatory Diseases
- Authors
- Lee, Ji Hyun; Cho, Dae Ho; Park, Hyun Jeong
- Issue Date
- Dec-2015
- Publisher
- MDPI
- Keywords
- IL-18; psoriasis; atopic dermatitis; urticaria; contact dermatitis; alopecia areata; drug eruption; lupus erythematosus; fibrosis; graft-versus-host disease; skin tumor; skin disease
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.12, pp 29357 - 29369
- Pages
- 13
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 16
- Number
- 12
- Start Page
- 29357
- End Page
- 29369
- ISSN
- 1661-6596
1422-0067
- Abstract
- Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.
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