PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Lee, Sung Ho | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Kim, Kibom | - |
dc.contributor.author | Ku, Sae Kwang | - |
dc.contributor.author | Youn, Jong Kyu | - |
dc.contributor.author | Cho, Su Bin | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Lee, Chi Hern | - |
dc.contributor.author | Son, Ora | - |
dc.contributor.author | Sohn, Eun Jeong | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.contributor.author | Kim, Hyun Ah | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.available | 2021-02-22T11:32:32Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10193 | - |
dc.description.abstract | FK506 binding protein 12 (FK506BP) is a small peptide with a single FK506BP domain that is involved in suppression of immune response and reactive oxygen species. FK506BP has emerged as a potential drug target for several inflammatory diseases. Here, we examined the protective effects of directly applied cell permeable FK506BP (PEP-1-FK506BP) on corneal alkali burn injury (CAI). In the cornea, there was a significant decrease in the number of cells expressing pro-inflammation, apoptotic, and angiogenic factors such as TNF-alpha, COX-2, and VEGF. Both corneal opacity and corneal neovascularization (CNV) were significantly decreased in the PEP-1-FK506BP treated group. Our results showed that PEP-1-FK506BP can significantly inhibit alkali burn-induced corneal inflammation in rats, possibly by accelerating corneal wound healing and by reducing the production of angiogenic factors and inflammatory cytokines. These results suggest that PEP-1-FK506BP may be a potential therapeutic agent for CAI. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2015.48.11.041 | - |
dc.identifier.scopusid | 2-s2.0-84950246145 | - |
dc.identifier.wosid | 000366095500005 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.48, no.11, pp 618 - 623 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 48 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 618 | - |
dc.citation.endPage | 623 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002049599 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | EYE BURNS | - |
dc.subject.keywordPlus | NEOVASCULARIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RABBIT | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordAuthor | Corneal alkali burn injury | - |
dc.subject.keywordAuthor | Corneal inflammation | - |
dc.subject.keywordAuthor | Corneal neovascularization | - |
dc.subject.keywordAuthor | PEP-1-FK506BP | - |
dc.subject.keywordAuthor | Protein therapy | - |
dc.identifier.url | http://koreascience.or.kr/article/JAKO201512037168417.page | - |
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