3 ' 4 ' 7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1
- Authors
- Kang, Ju-Hee; Lee, Juhyun; Moon, Miran; Yim, Mijung
- Issue Date
- Oct-2015
- Publisher
- GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
- Citation
- PHARMAZIE, v.70, no.10, pp 661 - 667
- Pages
- 7
- Journal Title
- PHARMAZIE
- Volume
- 70
- Number
- 10
- Start Page
- 661
- End Page
- 667
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10199
- DOI
- 10.1691/ph.2015.5575
- ISSN
- 0031-7144
- Abstract
- 3'4'7-Trihydroxyflavone is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin. In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the nnRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K, v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogen-activated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1. Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis via NFATc1.
- Files in This Item
-
Go to Link
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.