In vitro neuroprotective activity of sesquiterpenoids from the flower buds of Tussilago farfara
- Authors
- Lim, Hyo Jin; Dong, Guang-zhi; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- Oct-2015
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Neuroprotection; sesquiterpenoids; Tussilago farfara
- Citation
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.30, no.5, pp 852 - 856
- Pages
- 5
- Journal Title
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Volume
- 30
- Number
- 5
- Start Page
- 852
- End Page
- 856
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10214
- DOI
- 10.3109/14756366.2014.965701
- ISSN
- 1475-6366
1475-6374
- Abstract
- We have isolated four sesquiterpenoids from Tussilago farfara, a traditional herbal medicine in Korea and China, and investigated the protective effects on LPS-induced neuronal cell death. Four sesquiterpenoids inhibited the production of nitric oxide, prostaglandin E2 and tumor necrosis factor-a in LPS-treated BV-2 cells through the inhibition of NF-kappa B pathway. These sesquiterpenoids also inhibited reactive oxygen species (ROS) generation in LPS-treated BV-2 cells. Furthermore, they inhibited LPS-induced neuronal cell death in co-culture system through the inhibition of NF-kappa B pathway and scavenging of ROS. These results indicated that sesquiterpenoids from Tussilago farfara may have beneficial therapeutic potential for the treatment of neurodegenerative diseases through inhibition of microglial activation.
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