Diarylheptanoids from lesser galangal suppress human colon cancer cell growth through modulating Wnt/beta-catenin pathway
- Authors
- Dong, Guang-zhi; Lee, So Yoon; Zhao, Hui-Yuan; Lee, Yu-ih; Jeong, Ji Hye; Jeon, Raok; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- Oct-2015
- Publisher
- ELSEVIER
- Keywords
- Alpinia officinarum; Colon cancer; Diarylheptanoid; Lesser galangal; Wnt/beta-catenin pathway; Galectin-3
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.18, pp 47 - 57
- Pages
- 11
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 18
- Start Page
- 47
- End Page
- 57
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10217
- DOI
- 10.1016/j.jff.2015.06.059
- ISSN
- 1756-4646
2214-9414
- Abstract
- The Wnt/beta-catenin pathway plays a central role in cell growth and differentiation but abnormal activation causes colorectal carcinogenesis. Inhibiting the Wnt/beta-catenin pathway can be a good strategy for chemoprevention and treatment of colorectal cancer. While screening for Wnt/beta-catenin pathway inhibitors from food materials, we found that (E)-7-(4-hydroxy3-methoxyphenyl)-1-phenylhept-4-en-3-one (compound 1), among six diarylheptanoids from lesser galangal (Alpinia officinarum), most potently suppressed Wnt3a-induced beta-catenin/T-cell factor activity. Moreover, compound 1 suppressed proliferation of colon cancer cells by inhibiting beta-catenin translocation to the nucleus by disrupting the beta-catenin/galectin-3 complex. Furthermore, a structure-activity realtionship study implicated that the enone group in the linker is critical and the hydroxy substituent on the aromatic ring is generally preferred for activity. Our findings suggest that diarylheptanoid from lesser galangal exerts anti-colon cancer activity by down regulating the Wnt/beta-catenin pathway. Bioactive diarylheptanoids and the basic understanding of their structure-activity relationship could be utilized to develop potential candidates for beta-catenin-targeted cancer treatment. (C) 2015 Elsevier Ltd. All rights reserved.
- Files in This Item
-
Go to Link
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
- 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.