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Diarylheptanoids from lesser galangal suppress human colon cancer cell growth through modulating Wnt/beta-catenin pathway

Authors
Dong, Guang-zhiLee, So YoonZhao, Hui-YuanLee, Yu-ihJeong, Ji HyeJeon, RaokLee, Hwa JinRyu, Jae-Ha
Issue Date
Oct-2015
Publisher
ELSEVIER
Keywords
Alpinia officinarum; Colon cancer; Diarylheptanoid; Lesser galangal; Wnt/beta-catenin pathway; Galectin-3
Citation
JOURNAL OF FUNCTIONAL FOODS, v.18, pp 47 - 57
Pages
11
Journal Title
JOURNAL OF FUNCTIONAL FOODS
Volume
18
Start Page
47
End Page
57
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10217
DOI
10.1016/j.jff.2015.06.059
ISSN
1756-4646
2214-9414
Abstract
The Wnt/beta-catenin pathway plays a central role in cell growth and differentiation but abnormal activation causes colorectal carcinogenesis. Inhibiting the Wnt/beta-catenin pathway can be a good strategy for chemoprevention and treatment of colorectal cancer. While screening for Wnt/beta-catenin pathway inhibitors from food materials, we found that (E)-7-(4-hydroxy3-methoxyphenyl)-1-phenylhept-4-en-3-one (compound 1), among six diarylheptanoids from lesser galangal (Alpinia officinarum), most potently suppressed Wnt3a-induced beta-catenin/T-cell factor activity. Moreover, compound 1 suppressed proliferation of colon cancer cells by inhibiting beta-catenin translocation to the nucleus by disrupting the beta-catenin/galectin-3 complex. Furthermore, a structure-activity realtionship study implicated that the enone group in the linker is critical and the hydroxy substituent on the aromatic ring is generally preferred for activity. Our findings suggest that diarylheptanoid from lesser galangal exerts anti-colon cancer activity by down regulating the Wnt/beta-catenin pathway. Bioactive diarylheptanoids and the basic understanding of their structure-activity relationship could be utilized to develop potential candidates for beta-catenin-targeted cancer treatment. (C) 2015 Elsevier Ltd. All rights reserved.
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