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Stilbenoids from Rheum undulatum Protect Hepatocytes Against Oxidative Stress Through AMPK Activation

Authors
Dong, Guang-zhiLee, Yu-ihJeong, Ji HyeZhao, Hui-YuanJeon, RaokLee, Hwa JinRyu, Jae-Ha
Issue Date
Oct-2015
Publisher
WILEY
Keywords
Rheum undulatum; stilbenoid; hepatocyte protection; antioxidant; AMPK
Citation
PHYTOTHERAPY RESEARCH, v.29, no.10, pp 1605 - 1609
Pages
5
Journal Title
PHYTOTHERAPY RESEARCH
Volume
29
Number
10
Start Page
1605
End Page
1609
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10219
DOI
10.1002/ptr.5442
ISSN
0951-418X
1099-1573
Abstract
Oxidative stress promotes several diseases, including liver disease. We have isolated several stilbenoids from Rheum undulatum to investigate their hepatoprotective activities and mechanism. Stilbenoids from R. undulatum protects hepatocytes against arachidonic acid + iron (AA + Fe) induced oxidative stress. Pterostilbene (compound 5) shows stronger activity than the others. Trimethoxystilbenoid (compound 6) shows best activity on protection of HepG2 cells from AA + Fe-induced oxidative stress, and trans-stilbenoid (compound 7) shows weak activity. These stilbenoids suppress ROS generation in AA + Fe-treated HepG2 cells and also suppress AA + Fe-induced MMP disruption. Their protective effects on AA + Fe-induced MMP disruption were abrogated by treatment of AMP-activated protein kinase (AMPK) inhibitor, compound C or transfection of dominant negative form of AMPK. Taken together, stilbenoids from R. undulatum protect hepatocytes against AA + Fe-induced oxidative stress through AMPK activation. And the methoxy groups in the aryl groups are important for their cytoprotective activity. Copyright (c) 2015 John Wiley & Sons, Ltd.
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