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Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki
- Issue Date
- Jun-2003
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Broussonetia kazinoki; nitric oxides; kazinol B
- Citation
- FITOTERAPIA, v.74, no.4, pp 350 - 354
- Pages
- 5
- Journal Title
- FITOTERAPIA
- Volume
- 74
- Number
- 4
- Start Page
- 350
- End Page
- 354
- ISSN
- 0367-326X
1873-6971
- Abstract
- The ethyl acetate soluble fraction of Broussonetia kazinoki at 50 mug/ml showed a significant inhibition (78.2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC50 of 21.6 muM (C) 2003 Elsevier Science B.V. All rights reserved.
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