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Inhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi

Authors
Ahn, HKim, JYLee, HJKim, YKRyu, JH
Issue Date
Apr-2003
Publisher
PHARMACEUTICAL SOCIETY KOREA
Keywords
Artemisia iwayomogi; nitric oxide synthase; sesquiterpene; inhibitor
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.26, no.4, pp.301 - 305
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
26
Number
4
Start Page
301
End Page
305
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10316
DOI
10.1007/BF02976959
ISSN
0253-6269
Abstract
Nitric oxide (NO) is an important bioactive agent that mediates a wide variety of physiological and pathophysiological events. NO overproduction by inducible nitric oxide synthase (iNOS) results in severe hypotension and inflammation. This investigation is part of a study to discover new iNOS inhibitors from medicinal plants using a macrophage cell culture system. Two sesquiterpenes (1 and 2) were isolated from Artemisia iwayomogi (Compositae) and were found to inhibit NO synthesis (IC50 3.64 mug/mL and 2.81 mug/mL, respectively) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Their structures were identified as 3-O-methyl-isosecotanapartholide (1) and iso-secotanapartholide (2). Compounds 1 and 2 inhibited the LPS-induced expression of the iNOS enzyme in the RAW 264.7 cells. The inhibition of NO production via the down regulation of iNOS expression may substantially modulate the inflammatory responses.
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