Inhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi
- Authors
- Ahn, H; Kim, JY; Lee, HJ; Kim, YK; Ryu, JH
- Issue Date
- Apr-2003
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Keywords
- Artemisia iwayomogi; nitric oxide synthase; sesquiterpene; inhibitor
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.26, no.4, pp 301 - 305
- Pages
- 5
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 26
- Number
- 4
- Start Page
- 301
- End Page
- 305
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10316
- DOI
- 10.1007/BF02976959
- ISSN
- 0253-6269
1976-3786
- Abstract
- Nitric oxide (NO) is an important bioactive agent that mediates a wide variety of physiological and pathophysiological events. NO overproduction by inducible nitric oxide synthase (iNOS) results in severe hypotension and inflammation. This investigation is part of a study to discover new iNOS inhibitors from medicinal plants using a macrophage cell culture system. Two sesquiterpenes (1 and 2) were isolated from Artemisia iwayomogi (Compositae) and were found to inhibit NO synthesis (IC50 3.64 mug/mL and 2.81 mug/mL, respectively) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Their structures were identified as 3-O-methyl-isosecotanapartholide (1) and iso-secotanapartholide (2). Compounds 1 and 2 inhibited the LPS-induced expression of the iNOS enzyme in the RAW 264.7 cells. The inhibition of NO production via the down regulation of iNOS expression may substantially modulate the inflammatory responses.
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Collections - 약학대학 > 약학부 > 1. Journal Articles
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