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Characterization of antidepressant-like effects of p-synephrine stereoisomers

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dc.contributor.authorKim, KW-
dc.contributor.authorKim, HD-
dc.contributor.authorJung, JS-
dc.contributor.authorWoo, RS-
dc.contributor.authorKim, HS-
dc.contributor.authorSuh, HW-
dc.contributor.authorKim, YH-
dc.contributor.authorSong, DK-
dc.date.available2021-02-22T11:34:31Z-
dc.date.issued2001-07-
dc.identifier.issn0028-1298-
dc.identifier.issn1432-1912-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10439-
dc.description.abstractWe previously reported that p-synephrine has antidepressant-like activity in the murine models of forced swimming and tail suspension. In the present study, we characterized antidepressant-like effects of p-synephrine stereoisomers in both in vivo and in vitro systems. In the tail suspension test, S-(+)-p-synephrine (3 mg/kg, p.o.) reduced the duration of immobility, while R-(-)-p-synephrine (0.3-3 mg/kg, p.o.) had no effect. S-(+)-p-synephrine (0.3, 1 and 3 mg/kg, p.o.) and R-(-)-p-synephrine (1 mg/kg and 3 mg/kg, p.o.) significantly reversed the reserpine (2.5 mg/kg, i.p.)-induced hypothermia. S-(+)-p-synephrine was more effective than R-(-)-p-synephrine in inhibition of both [H-3]noradrenaline uptake in rat cerebral cortical slices (maximal inhibition 85.7 +/-7.8% vs. 59.8 +/-4.3%; EC50 5.8 +/-0.7 muM vs. 13.5 +/-1.2 muM) and [H-3]nisoxetine binding (K-i 4.5 +/-0.5 muM vs. 8.2 +/-0.7 muM). In contrast, R-(-)-p-synephrine was more effective than S-(+)-p-synephrine in stimulation of [H-3]noradrenaline release from rat cerebral cortical slices (maximal stimulation 23.9 +/-1.8% vs. 20.1 +/-1.7%; EC50 8.2 +/-0.6 muM vs. EC50 12.3 +/-0.9 muM). The stimulatory effect of R-(-)-p-synephrine on [H-3]noradrenaline release was inhibited by nisoxetine (100 nM), but tetrodotoxin (1 muM) and elimination of extracellular calcium had no effect. It is suggested that S-(+)-p-synephrine has more effective antidepressant-like activity than R-(-)-p-synephrine.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGER-VERLAG-
dc.titleCharacterization of antidepressant-like effects of p-synephrine stereoisomers-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1007/s002100100416-
dc.identifier.scopusid2-s2.0-0034945029-
dc.identifier.wosid000169533600004-
dc.identifier.bibliographicCitationNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v.364, no.1, pp 21 - 26-
dc.citation.titleNAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY-
dc.citation.volume364-
dc.citation.number1-
dc.citation.startPage21-
dc.citation.endPage26-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusADRENOCEPTORS-
dc.subject.keywordPlusOCTOPAMINE-
dc.subject.keywordAuthorS-(+)-p-synephrine-
dc.subject.keywordAuthorR-(-)-p-synephrine-
dc.subject.keywordAuthorantidepressants-
dc.subject.keywordAuthortail suspension test-
dc.subject.keywordAuthorreserpine-
dc.subject.keywordAuthor[H-3]noradrenaline uptake-
dc.subject.keywordAuthor[H-3]noradrenaline release-
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