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The role of toll-like receptors in osteoclastogenesis

Authors
Yim, Mijung
Issue Date
Nov-2020
Publisher
Korean Society for Bone and Mineral Research
Keywords
Bone diseases · Osteoclasts · Osteolysis
Citation
Journal of Bone Metabolism, v.27, no.4, pp 227 - 235
Pages
9
Journal Title
Journal of Bone Metabolism
Volume
27
Number
4
Start Page
227
End Page
235
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1053
DOI
10.11005/JBM.2020.27.4.227
ISSN
2287-6375
2287-7029
Abstract
Bone homeostasis is maintained by a balance in the levels of osteoclast and osteoblast activity. Osteoclasts are bone-resorbing cells and have been shown to act as key players in various osteolytic diseases. Osteoclasts differentiate from monocyte/macrophage lineage cells in the presence of receptor activator of nuclear factor-κB ligand and macrophage colony-stimulating factor. Osteoblasts support osteoclastogenesis by producing several osteoclast differentiation factors. Toll-like receptors (TLRs) are members of the pattern recognition receptor family that are involved in recognizing pathogen-associated molecular patterns and damage-associated molecular patterns in response to pathogen infection. TLRs regulate osteoclastogenesis and bone resorption through either the myeloid differentiation primary response 88 or the Toll/interleukin-1 receptor domain-containing adapter-inducing interferon-β signaling pathways. Since osteoclasts play a central role in the progression of osteolytic diseases, extensive research focusing on TLR downstream signaling in these cells should be conducted to advance the development of effective TLR modulators. In this review, we summarize the currently available information on the role of TLRs in osteoclast differentiation and osteolytic diseases. Copyright © 2020 The Korean Society for Bone and Mineral Research
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