Inhibition of LPS-induced NO production and NF-kappa B activation by a sesquiterpene from Saussurea lappa
- Authors
- Jin, MR; Lee, HJ; Ryu, JH; Chung, KS
- Issue Date
- Feb-2000
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Keywords
- dehydrocostus lactone; sesquiterpene lactone; Saussurea lappa; nitric oxide; inducible nitric oxide synthase; NF-kappa-B
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.23, no.1, pp 54 - 58
- Pages
- 5
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 23
- Number
- 1
- Start Page
- 54
- End Page
- 58
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10545
- DOI
- 10.1007/BF02976467
- ISSN
- 0253-6269
1976-3786
- Abstract
- To elucidate the molecular mechanisms for the suppression of LPS-induced nitric oxide (NO) production by a dehydrocostus lactone (DL) from Saussurea lappa, we examined the preventive effect of this compound on NF-kappa B activation in LPS-treated RAW 264.7 macrophages and U937 human monocytic cells. The results suggest that the suppression of NO production is mediated by the inhibitory action on the i-NOS gene expression through the inactivation of NF-kappa B and this sesquiterpene lactone can act as a pharmacological inhibitor of the NF-kappa B activation.
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