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New Cytotoxic Sesquiterpenoids from Siegesbeckia glabrescens

Authors
Wu, QianLi, HuaLee, So YoonLee, Hwa JinRyu, Jae-Ha
Issue Date
Feb-2015
Publisher
MDPI
Keywords
Compositae; Cytotoxicity; Sesquiterpenoids; Siegesbeckia glabrescens
Citation
MOLECULES, v.20, no.2, pp 2850 - 2856
Pages
7
Journal Title
MOLECULES
Volume
20
Number
2
Start Page
2850
End Page
2856
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10688
DOI
10.3390/molecules20022850
ISSN
1420-3049
Abstract
Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 mu M.
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