Detailed Information

Cited 0 time in webofscience Cited 8 time in scopus
Metadata Downloads

Kazinol-P from Broussonetia kazinoki enhances skeletal muscle differentiation via p38MAPK and MyoD

Authors
Hwang, JeongmiLee, Sang-JinYoo, MiranGo, Ga-YeonLee, Da YeonKim, Yong-KeeSeo, Dong-WanKang, Jong-SunRyu, Jae-HaBae, Gyu-Un
Issue Date
Jan-2015
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Broussonetia kazinoki; Myoblast differentiation; MyoD; Kazinol-P; p38MAPK; Trans-differentiation
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.456, no.1, pp 471 - 475
Pages
5
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
456
Number
1
Start Page
471
End Page
475
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10701
DOI
10.1016/j.bbrc.2014.11.109
ISSN
0006-291X
1090-2104
Abstract
The activation of MyoD family transcription factors is critical for myogenic differentiation, which is fundamental to the regeneration of skeletal muscle after injury. Kazinol-P (KP) from Broussonetia kazinoki (B. kazinoki), a natural compound, has been reported to possess an anti-oxidant function. In a screen of natural compounds for agonists of the MyoD activity, we identified KP and examined its effect on myoblast differentiation. Consistently, KP enhanced the myotube formation, accompanied with upregulation of myogenic markers such as MHC, Myogenin and Troponin-T. KP treatment in C2C12 myoblasts led to strong activation of a key promyogenic kinase p38MAPK in a dose, and time-dependent manner. Furthermore, KP treatment enhanced the MyoD-mediated trans-differentiation of 10T1/2 fibroblasts into myoblasts. Taken together, KP promotes myogenic differentiation through activation of p38MAPK and MyoD transcription activities. Thus KP may be a potential therapeutic candidate to prevent fibrosis and improve muscle regeneration and repair. (C) 2014 Elsevier Inc. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Bae, Gyu Un photo

Bae, Gyu Un
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE