Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells
- Authors
- Shim, Ah-Ram; Dong, Guang-Zhi; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- Jan-2015
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Atractylochromene; Wnt/beta-catenin; Colon cancer; Proliferation
- Citation
- BIOMOLECULES & THERAPEUTICS, v.23, no.1, pp 26 - 30
- Pages
- 5
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 23
- Number
- 1
- Start Page
- 26
- End Page
- 30
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10716
- DOI
- 10.4062/biomolther.2014.095
- ISSN
- 1976-9148
2005-4483
- Abstract
- Wnt/beta-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated beta-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes. In this study, we identified an inhibitor of beta-catenin dependent Wnt pathway from rhizomes of Atractylodes macrocephala Koidzumi (Compositae). The active compound was purified by activity-guided purification and the structure was identified as 2,8-dimethyl-6-hydroxy-2-(4-methyl-3-pentenyl)-2H-chromene (atractylochromene, AC). AC suppressed beta-catenin/T-cell factor transcriptional activity of HEK-293 reporter cells when they were stimulated by Wnt3a or inhibitor of glycogen synthase kinase-3 beta. AC down-regulated the nuclear level of beta-catenin through the suppression of galectin-3 mediated nuclear translocation of beta-catenin in SW-480 colon cancer cells. Furthermore, AC inhibits proliferation of colon cancer cell. Taken together, AC from A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
- Files in This Item
-
Go to Link
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
- 이과대학 > 생명시스템학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.