Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells
DC Field | Value | Language |
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dc.contributor.author | Pyo, Myoung Yun | - |
dc.contributor.author | Yoon, Soo Jeong | - |
dc.contributor.author | Yu, Yeonsil | - |
dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Jin, Mirim | - |
dc.date.available | 2021-02-22T11:48:34Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10887 | - |
dc.description.abstract | Allergic disease is dominated by Th2 immune responses. Interleukin (IL)-4 and IL-13, representative Th2 cytokines, play pivotal roles in the pathogenic activation of the Th2 immune response. In this study, we found that cyanidin-3-glucoside chloride (C3G), an anthocyanin suppressed IL-4 and IL-13 produced in activated EL-4 T cells but not Th1 cytokines including IL-2, interferon-gamma, or IL-12. IL-4 and IL-13 mRNA levels and luciferase activation in cells transiently transfected with IL-4 and IL-13 promoter reporter plasmids were significantly inhibited by C3G, suggesting that suppression might be, at least in part, regulated at the transcriptional level. Data from western blot and reverse transcription-polymerase chain reaction analyses of transcription factors involved in cytokine expression suggested that expression of GATA-3, but not T-bet, was downregulated in the nucleus by C3G. Taken together, our data indicate that C3G may has potential as an anti-allergic agent suppressing Th2 activation by downregulating Th2 cytokines and the GATA3 transcription factor in allergies. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/09168451.2014.912115 | - |
dc.identifier.scopusid | 2-s2.0-84925862302 | - |
dc.identifier.wosid | 000340133800019 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.78, no.6, pp 1037 - 1043 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 78 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1037 | - |
dc.citation.endPage | 1043 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | ALLERGIC AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | VITRO TEST SYSTEM | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | ANTHOCYANINS | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | BET | - |
dc.subject.keywordPlus | HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | PHYTOCHEMICALS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordAuthor | interleukin-4 (IL-4) | - |
dc.subject.keywordAuthor | interleukin-13 (IL-13) | - |
dc.subject.keywordAuthor | cyaniding-3-glucoside (C3G) C3G | - |
dc.subject.keywordAuthor | GATA-binding protein 3 (GATA-3) | - |
dc.subject.keywordAuthor | anti-allergic agent | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/09168451.2014.912115 | - |
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