Specificity Protein 1 Expression Contributes to Bcl-w-Induced Aggressiveness in Glioblastoma Multiforme
DC Field | Value | Language |
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dc.contributor.author | Lee, Woo Sang | - |
dc.contributor.author | Kwon, Junhye | - |
dc.contributor.author | Yun, Dong Ho | - |
dc.contributor.author | Lee, Young Nam | - |
dc.contributor.author | Woo, Eun Young | - |
dc.contributor.author | Park, Myung-Jin | - |
dc.contributor.author | Lee, Jae-Seon | - |
dc.contributor.author | Han, Young-Hoon | - |
dc.contributor.author | Bae, In Hwa | - |
dc.date.available | 2021-02-22T12:01:46Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11027 | - |
dc.description.abstract | We already had reported that Bcl-w promotes invasion or migration in gastric cancer cells and glioblastoma multiforme (GBM) by activating matrix metalloproteinase-2 (MMP-2) via specificity protein 1 (Sp1) or beta-cateinin, respectively. High expression of Bcl-w also has been reported in GBM which is the most common malignant brain tumor and exhibits aggressive and invasive behavior. These reports propose that Bcl-w-induced signaling is strongly associated with aggressive characteristic of GBM. We demonstrated that Sp1 protein or mRNA expression is induced by Bcl-w using Western blotting or RT-PCR, respectively, and markedly elevated in high-grade glioma specimens compared with low-grade glioma tissues using tissue array. However, relationship between Bcl-w-related signaling and aggressive characteristic of GBM is poorly characterized. This study suggested that Bcl-w-induced Sp1 activation promoted expression of glioma stem-like cell markers, such as Musashi, Nanog, Oct4 and sox-2, as well as neurosphere formation and invasiveness, using western blotting, neurosphere formation assay, or invasion assay, culminating in their aggressive behavior. Therefore, Bcl-w-induced Sp1 activation is proposed as a putative marker for aggressiveness of GBM. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Specificity Protein 1 Expression Contributes to Bcl-w-Induced Aggressiveness in Glioblastoma Multiforme | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.14348/molcells.2014.2161 | - |
dc.identifier.scopusid | 2-s2.0-84901457154 | - |
dc.identifier.wosid | 000342559100003 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.37, no.1, pp 17 - 23 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 23 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001847544 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR SP1 | - |
dc.subject.keywordPlus | DNA-BINDING ACTIVITY | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | aggressiveness | - |
dc.subject.keywordAuthor | Bcl-w | - |
dc.subject.keywordAuthor | glioblastoma multiforme | - |
dc.subject.keywordAuthor | glioma stem cell markers | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | Sp1 | - |
dc.identifier.url | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2014.2161 | - |
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