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충울자 EtOAc 분획의 항알러지 및 항염증 효과Anti-allergic and Anti-inflammatory Effect of Leonurus sibiricus Seed Ethyl Acetate Fractions

Other Titles
Anti-allergic and Anti-inflammatory Effect of Leonurus sibiricus Seed Ethyl Acetate Fractions
Authors
정유정전영식김형자강기성김용기김수남
Issue Date
Oct-2014
Publisher
대한약학회
Keywords
Leonurus sibiricus seed; anti-allergy; anti-inflammation
Citation
약 학 회 지, v.58, no.5, pp 294 - 299
Pages
6
Journal Title
약 학 회 지
Volume
58
Number
5
Start Page
294
End Page
299
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11085
ISSN
0377-9556
Abstract
In this study, we investigate anti-allergic and anti-inflammatory effects of Leonurus sibiricus seed (LSS) extractin basophilic leukemia RBL-2H3 cells. To identify anti-allergic actions of LSS, the degranulation was evaluated in IgE andDNP-BSA stimulated RBL-2H3 cells. At the concentration of 100 μg/ml of methanol (MeOH) extract and Methylene chloride(MC) and Ethyl acetate (EtOAc) fractions, the degranulation was significantly inhibited 16.7%, 16.7% and 27.9% respectively. And then, to assess anti-inflammatory effects of LSS, IL-4 and IL-13 mRNA level were detected in PMA/ionomycin(PI)-induced RBL-2H3 cells and cell proliferation and IL-4 mRNA level in isolated splenocytes from Balb/c mice. LSSMeOH extract and MC and EtOAc fractions significantly decreased the level of IL-4 and IL-13 mRNA in PI-induced RBL-2H3 cells and showed inhibitory effects on cell proliferation and expression of IL-4 mRNA level in mouse splenocytes. Taken together, these results suggest that LSS has potential anti-allergic and anti-inflammatory effects and EtOAc fractionis the most effective in regulating immune responses.
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