Detailed Information

Cited 0 time in webofscience Cited 4 time in scopus
Metadata Downloads

Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency

Authors
Ahn, Eun HeeKim, Dae WonShin, Min JeaJo, Hyo SangEom, Seon AeKim, Duk-SooPark, Eun YoungPark, Jong HoonCho, Sung-WooPark, JinseuEum, Won SikSon, OraHwang, Hyun SookChoi, Soo Young
Issue Date
Nov-2013
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Keywords
Fenobam; Ischemic damage; Neuroprotection; PEP-1-FK506BP; Protein transduction domains
Citation
BMB REPORTS, v.46, no.11, pp 561 - 566
Pages
6
Journal Title
BMB REPORTS
Volume
46
Number
11
Start Page
561
End Page
566
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11177
DOI
10.5483/BMBRep.2013.46.11.080
ISSN
1976-6696
1976-670X
Abstract
We examined the ways in which fenobam could promote not only the transduction of PEP-1-FK506BP into cells and tissues but also the neuroprotective effect of PEP-1-FK506BP against ischemic damage. Fenobam strongly enhanced the protective effect of PEP-1-FK506BP against H2O2-induced toxicity and DNA fragmentation in C6 cells. In addition, combinational treatment of fenobam with PEP-1-FK506BP significantly inhibited the activation of Akt and MAPK induced by H2O2, compared to treatment with PEP-1-FK506BP alone. Interestingly, our results showed that fenobam significantly increased the transduction of PEP-1-FK506BP into both C6 cells and the hippocampus of gerbil brains. Subsequently, a transient ischemic gerbil model study demonstrated that fenobam pretreatment led to the increased neuroprotection of PEP-1-FK506BP in the CA1 region of the hippocampus. Therefore, these results suggest that fenobam can be a useful agent to enhance the transduction of therapeutic PEP-1-fusion proteins into cells and tissues, thereby promoting their neuroprotective effects.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Jong Hoon photo

Park, Jong Hoon
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE