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Oncogenic function of p34(SEI-1) via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway
- Authors
- Jung, Samil; Li, Chengping; Jeong, Dongjun; Lee, Soonduck; Ohk, Jiyeon; Park, Meeyoung; Han, Songyi; Duan, Jingjing; Kim, Changjin; Yang, Young; Kim, Keun-Il; Lim, Jong-Seok; Kang, Young-Sook; Lee, Myeong-Sok
- Issue Date
- Nov-2013
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- 34-KD protein encoding selected with Ink4a-1 as bait gene; phosphatase and tensin homolog deleted on chromosome ten; neuronal precursor cell-expressed developmentally downregulated 4-1; phosphoinositide-3 kinase/protein kinase B; tumorigenesis
- Citation
- INTERNATIONAL JOURNAL OF ONCOLOGY, v.43, no.5, pp 1587 - 1595
- Pages
- 9
- Journal Title
- INTERNATIONAL JOURNAL OF ONCOLOGY
- Volume
- 43
- Number
- 5
- Start Page
- 1587
- End Page
- 1595
- ISSN
- 1019-6439
1791-2423
- Abstract
- A 34-KD protein encoded by the SEI-1 gene (p34(SEI-1)), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34(SEI-1) enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34(SEI-1) positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34(SEI-1) and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34(SEI-1) affects the subcellular localization of PTEN.
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