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(-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-kappa B alpha degradation in LPS-stimulated BV-2 microglial cells

Authors
Lee, Hwa JinLi, HuaChang, Hee RyunJung, HyeyounLee, Da YeonRyu, Jae-Ha
Issue Date
Oct-2013
Publisher
INFORMA HEALTHCARE
Keywords
(-)-nyasol; microglia; neuroinflammation; NF-kappa B
Citation
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.28, no.5, pp 954 - 959
Pages
6
Journal Title
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume
28
Number
5
Start Page
954
End Page
959
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11216
DOI
10.3109/14756366.2012.697057
ISSN
1475-6366
1475-6374
Abstract
Microglial activation has been associated with neurodegenerative diseases by inducing the neuroinflammatory mediators such as nitric oxide (NO), TNF-alpha and IL-1 beta. (-)-Nyasol, a norlignan isolated from a medicinal plant Anemarrhena asphodeloides, showed anti-inflammatory potential in lipopolysaccharide (LPS)-activated BV-2 microglial cells. (-)-Nyasol inhibited the production of NO and prostaglandin E-2 (PGE(2)) and also the expression of inducible nitric oxide synthase and cyclooxygenase-2, which are responsible for the respective production of NO and PGE(2). It also suppressed the mRNA levels of TNF-alpha and IL-1 beta in activated microglial cells. These effects of (-)-nyasol were correlated with the inactivation of p38 MAPK and the suppression of LPS-induced I-kappa B alpha degradation. Taken together, these results suggest that (-)-nyasol can be a modulator in neuroinflammatory conditions induced by microglial activation.
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