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Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development

Authors
Kim, YujinPark, EunjeongNoh, HyunaPark, Soochul
Issue Date
Sep-2013
Publisher
WILEY-BLACKWELL
Keywords
EphA; ephrin-A; apoptosis; early brain development
Citation
DEVELOPMENTAL NEUROBIOLOGY, v.73, no.9, pp 702 - 712
Pages
11
Journal Title
DEVELOPMENTAL NEUROBIOLOGY
Volume
73
Number
9
Start Page
702
End Page
712
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11228
DOI
10.1002/dneu.22092
ISSN
1932-8451
1932-846X
Abstract
EphAs and ephrin-As are expressed in multiple regions of the developing brain and have been implicated in regulating brain size. Here, we report the identification of a novel mechanism in which reverse signaling through ephrin-As controls neural epithelial cell number in the developing brain. Ectopic expression of EphA8-Fc in transgenic embryos induced apoptosis of neural epithelial cells, which was accompanied by a dramatic decrease in brain size. The number of ephrin-A5-expressing cells was significantly reduced in the brain region where EphA8-Fc was ectopically expressed. Furthermore, in vitro culture of the dissociated neuroepithelial cells revealed that EphA8-Fc enhanced apoptotic cell death of the ephrinA5-expressing cells in a caspase-dependent manner. Thus, our results suggest that reverse signaling through ephrin-As is biochemically linked with caspase-dependent proapoptotic signaling during early brain development. (c) 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 702-712, 2013
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