Effect of Korean pear (Pyruspyrifolia cv. Shingo) juice on hangover severity following alcohol consumption
- Authors
- Lee, Ho-Sun; Isse, Toyohi; Kawamoto, Toshihiro; Baik, Hyun Wook; Park, Jong Y.; Yang, Mihi
- Issue Date
- Aug-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Alcohol; Hangover; Korean pear; ALDH2; Pharmacokinetics; Pharmacodynamics
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.58, pp 101 - 106
- Pages
- 6
- Journal Title
- FOOD AND CHEMICAL TOXICOLOGY
- Volume
- 58
- Start Page
- 101
- End Page
- 106
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11247
- DOI
- 10.1016/j.fct.2013.04.007
- ISSN
- 0278-6915
1873-6351
- Abstract
- Korean pear has been used as a traditional prophylactic agent for alcohol hangover. However, its mechanism was not investigated in human yet. Therefore, we performed a randomized single blind crossover trial with 14 healthy young men to examine effects of Korean pear juice on alcohol hangover. All subjects consumed 540 ml of spirits (alcohol conc. 20.1 v/v%) after 30 min from the intervention, i.e. placebo or Korean pear juice treatment. Blood and urine specimens were collected in time-courses (9 time-points for 15 h after alcohol consumption). The total and average of hangover severity were alleviated to 16% and 21% by Korean pear juice at 15 h after the alcohol consumption, respectively (ps < 0.05). Particularly, 'trouble concentrating' was significantly improved by the pear juice treatment (p < 0.05). Impaired memory, and sensitivity to light and sound were significantly improved by Korean pear juice among the subjects with ALDH2*1/*1 or ALDH2*1/*2 genotypes (ps < 0.05) but not in the subjects with ALDH2*2/*2 genotype. In addition, the pear juice treatment lowered levels of blood alcohol (p < 0.01). Therefore, Korean pear juice may alleviate alcohol-hangover and its detoxification of alcohol seems to be modified by the genetic variation of ALDH2. (C) 2013 Elsevier Ltd. All rights reserved.
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