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Somatic mutation patterns and compound response in cancers

Authors
He, NingningKim, NayoungYoon, Sukjoon
Issue Date
Feb-2013
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Keywords
Cancer mutation; Cell line enrichment analysis; Compound response; GI(50); NCI60
Citation
BMB REPORTS, v.46, no.2, pp 97 - 102
Pages
6
Journal Title
BMB REPORTS
Volume
46
Number
2
Start Page
97
End Page
102
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11333
DOI
10.5483/BMBRep.2013.46.2.226
ISSN
1976-6696
1976-670X
Abstract
The use of various cancer cell lines can recapitulate known tumor-associated mutations and genetically define cancer subsets. This approach also enables comparative surveys of associations between cancer mutations and drug responses. Here, we analyzed the effects of similar to 40,000 compounds on cancer cell lines that showed diverse mutation-dependent sensitivity profiles. Over 1,000 compounds exhibited unique sensitivity on cell lines with specific mutational genotypes, and these compounds were clustered into six different classes of mutation-oriented sensitivity. The present analysis provides new insights into the relationship between somatic mutations and selectivity response of chemicals, and these results should have applications related to predicting and optimizing therapeutic windows for anti-cancer agents. [BMB Reports 2013; 46(2): 97-102]
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