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Body mass index and survival in patients with renal cell carcinoma: A clinical-based cohort and meta-analysis

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dc.contributor.authorChoi, Yuni-
dc.contributor.authorPark, Bumsoo-
dc.contributor.authorJeong, Byong Chang-
dc.contributor.authorIl Seo, Seong-
dc.contributor.authorJeon, Seong Soo-
dc.contributor.authorChoi, Han Yong-
dc.contributor.authorAdami, Hans-Olov-
dc.contributor.authorLee, Jung Eun-
dc.contributor.authorLee, Hyun Moo-
dc.date.available2021-02-22T12:16:49Z-
dc.date.created2020-09-03-
dc.date.issued2013-02-01-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11343-
dc.description.abstractGrowing evidence suggests that obesity, an established cause of renal cell cancer (RCC), may also be associated with a better prognosis. To evaluate the association between RCC survival and obesity, we analyzed a large cohort of patients with RCC and undertook a meta-analysis of the published evidence. We collected clinical and pathologic data from 1,543 patients who underwent nephrectomy for RCC between 1994 and 2008 with complete follow-up through 2008. Patients were grouped according to BMI (kg/m2): underweight <18.5, normal weight 18.5 to <23, overweight 23 to <25 and obese =25. We estimated survival using the KaplanMeier method and Cox proportional hazard models to examine the impact of BMI on overall survival (OS) and cancer-specific survival (CSS) with adjustment for covariates. We performed a meta-analysis of BMI and OS, CSS and recurrence-free survival (RFS) from all relevant studies using a random-effects model. The 5-year CSS increased from 76.1% in the lowest to 92.7% in the highest BMI category. A multivariate analysis showed higher OS [hazard ratio (HR) = 0.45; 95% CI: 0.290.68) and CSS (HR = 0.47; 95% CI: 0.290.77] in obese patients than in normal weight patients. The meta-analysis further corroborated that high BMI significantly improved OS (HR = 0.57; 95% CI: 0.430.76), CSS (HR = 0.59; 95% CI: 0.480.74) and RFS (HR = 0.49; 95% CI: 0.300.81). Our study shows that preoperative BMI is an independent prognostic indicator for survival among patients with RCC.-
dc.language영어-
dc.language.isoen-
dc.publisherWILEY-
dc.subjectPROGNOSTIC-SIGNIFICANCE-
dc.subjectRADICAL NEPHRECTOMY-
dc.subjectHEART-FAILURE-
dc.subjectCANCER-
dc.subjectOBESITY-
dc.subjectOVERWEIGHT-
dc.subjectMORTALITY-
dc.subjectIMPACT-
dc.titleBody mass index and survival in patients with renal cell carcinoma: A clinical-based cohort and meta-analysis-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.identifier.doi10.1002/ijc.27639-
dc.identifier.scopusid2-s2.0-84870253414-
dc.identifier.wosid000311620100020-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, v.132, no.3, pp.625 - 634-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.citation.titleINTERNATIONAL JOURNAL OF CANCER-
dc.citation.volume132-
dc.citation.number3-
dc.citation.startPage625-
dc.citation.endPage634-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOncology-
dc.relation.journalWebOfScienceCategoryOncology-
dc.subject.keywordPlusPROGNOSTIC-SIGNIFICANCE-
dc.subject.keywordPlusRADICAL NEPHRECTOMY-
dc.subject.keywordPlusHEART-FAILURE-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusOVERWEIGHT-
dc.subject.keywordPlusMORTALITY-
dc.subject.keywordPlusIMPACT-
dc.subject.keywordAuthorrenal cell carcinoma-
dc.subject.keywordAuthorbody mass index-
dc.subject.keywordAuthorsurvival-
dc.subject.keywordAuthormeta-analysis-
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생활과학대학 > 식품영양학과 > 1. Journal Articles

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