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Thiacremonone, a sulfur compound isolated from garlic, attenuates lipid accumulation partially mediated via AMPK activation in 3T3-L1 adipocytes

Authors
Kim, Eun JinLee, Dong HunKim, Hee JongLee, So JungBan, Jung OkCho, Min ChulJeong, Heon SangYang, YoungHong, Jin TaeYoon, Do Young
Issue Date
Dec-2012
Publisher
ELSEVIER SCIENCE INC
Keywords
Thiacremonone; Adipocyte; AMPK; Bioflavonoid; PPAR gamma
Citation
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.23, no.12, pp 1552 - 1558
Pages
7
Journal Title
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume
23
Number
12
Start Page
1552
End Page
1558
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11809
DOI
10.1016/j.jnutbio.2011.10.008
ISSN
0955-2863
1873-4847
Abstract
Garlic extracts exert anti-cancer and anti-inflammatory effects. However, the anti-adipogenic effect of garlic-derived compounds remains unclear. In this study, we examined the effect of thiacremonone, a sulfur compound isolated from garlic, on adipocyte differentiation using 3T3-L1 cells. We found that thiacremonone significantly inhibited 3T3-L1 differentiation via down-regulation of adipogenesis-related transcription factors and adipogenic markers. The inhibitory effect mainly occurred at the early phase of differentiation in 3T3-L1 cells. There was no cytotoxic effect of thiacremonone in 3T3-L1 cells and treatment of differentiating 3T3-L1 cells with thiacremonone resulted in AMPK activation, which led to an attenuated expression of acetyl CoA carboxylase-1 (ACC-1), an essential enzyme for the synthesis and usage of fatty acids. Moreover, thiacremonone enhanced the mRNA level of carnitine palmitoyltransferase (CPT-1). The modulating effect of thiacremonone on expressions of genes involved in lipolysis was partially abrogated by treatment with compound C, an AMPK inhibitor. Taken together, these results indicated that thiacremonone-induced AMPK activation, inhibition of ACC-1 expression and concomitant recovery of CPT-1 expression resulted in the suppression of intracellular lipid droplet levels, suggesting that thiacremonone may induce reduction of lipid synthesis and increases in fatty acid oxidation partially mediated via AMPK activation. Thiacremonone may be a promising compound for the treatment of obesity. (C) 2012 Elsevier Inc. All rights reserved.
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