Characterization and function of human Ly-6/uPAR molecules
- Authors
- Kong, Hyun Kyung; Park, Jong Hoon
- Issue Date
- Nov-2012
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Cancer metastasis; Cancer therapy; Gene family; Hematopoiesis; Immune system; Tumorigenesis
- Citation
- BMB REPORTS, v.45, no.11, pp 595 - 603
- Pages
- 9
- Journal Title
- BMB REPORTS
- Volume
- 45
- Number
- 11
- Start Page
- 595
- End Page
- 603
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11814
- DOI
- 10.5483/BMBRep.2012.45.11.210
- ISSN
- 1976-6696
1976-670X
- Abstract
- Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GIN-anchor and the other are secreted proteins without the GIN-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy. [BMB Reports 2012; 45(11): 595-603]
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