Phenolic glycosides as inhibitors of inducible nitric oxide synthase from Populus davidiana in LPS-activated RAW 264.7 murine macrophages
- Authors
- Lee, Hwa Jin; Kim, Ji Sun; Kim, Young-Kyoon; Ryu, Jae-Ha
- Issue Date
- Oct-2012
- Publisher
- GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
- Citation
- PHARMAZIE, v.67, no.10, pp 870 - 873
- Pages
- 4
- Journal Title
- PHARMAZIE
- Volume
- 67
- Number
- 10
- Start Page
- 870
- End Page
- 873
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11836
- DOI
- 10.1691/ph.2012.1869
- ISSN
- 0031-7144
- Abstract
- Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (i-NOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of i-NOS, thus, may be useful candidates for the treatment of inflammatory diseases that accompany the overproduction of NO. Two phenolic glycosides, salicortin (1) and salicortin-6'-benzoate (2), were purified as active principles from the extracts of Populus davidiana by activity-guided purification procedures. They showed dose dependent inhibition of NO production in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The IC50 values of salicortin (1) and salicortin-6'-benzoate (2) was 15 mu M and over 50 rho M, respectively. In immunoblot analysis, salicortin inhibited the expression of i-NOS. These new inhibitors of overproduction of NO may have potentials for the treatment of inflammation.
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