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Oral administration of fermented red ginseng suppressed ovalbumin-induced allergic responses in female BALB/c mice

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dc.contributor.authorLee, Eun-Ju-
dc.contributor.authorSong, Min-Ji-
dc.contributor.authorKwon, Hye-Soon-
dc.contributor.authorJi, Geun Eog-
dc.contributor.authorSung, Mi-Kyung-
dc.date.available2021-02-22T12:46:01Z-
dc.date.issued2012-07-15-
dc.identifier.issn0944-7113-
dc.identifier.issn1618-095X-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11864-
dc.description.abstractAnti-allergic efficacy of red ginseng (RG) and fermented red ginseng (FRG) was evaluated. RG or FRG were administered to ovalbumin (OVA)-sensitized mice for 8 weeks. Immunoglobulins (Igs), Th1/Th2 type cytokines, and P-lactoglobulin (BLG) in serum, and intestinal barrier-related molecules in jejunum were measured using enzyme-linked immunosorbent assay or reverse transcription-polymerase chain reaction. Mice sensitized with OVA increased serum IgG(1), IgE, OVA-IgG(1), and OVA-IgE. Both RG and FRG decreased serum IgE, OVA-IgE, and pro-inflammatory cytokines. Serum BLG, a marker of gut permeability, was significantly higher in sensitized animals and was decreased in mice fed RG or FRG. In addition, intestinal barrier-related markers such as MMCP-1, IL-4, TNF-alpha, COX-2, and iNOS mRNA expressions were decreased by RG or FRG. Our results suggest in vivo anti-allergic activities of RG or FRG, which are associated with the regulation of Th1/Th2 balance, intestinal inflammation and subsequent the suppression of IgE. (C) 2012 Elsevier GmbH. All rights reserved.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherELSEVIER GMBH-
dc.titleOral administration of fermented red ginseng suppressed ovalbumin-induced allergic responses in female BALB/c mice-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.1016/j.phymed.2012.04.008-
dc.identifier.scopusid2-s2.0-84864402638-
dc.identifier.wosid000309640600007-
dc.identifier.bibliographicCitationPHYTOMEDICINE, v.19, no.10, pp 896 - 903-
dc.citation.titlePHYTOMEDICINE-
dc.citation.volume19-
dc.citation.number10-
dc.citation.startPage896-
dc.citation.endPage903-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaIntegrative & Complementary Medicine-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryIntegrative & Complementary Medicine-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusINTESTINAL PERMEABILITY-
dc.subject.keywordPlusANTIALLERGIC ACTIVITY-
dc.subject.keywordPlusFOOD ALLERGY-
dc.subject.keywordPlusCELL-
dc.subject.keywordAuthorFood allergy-
dc.subject.keywordAuthorGut permeability-
dc.subject.keywordAuthorIgE-
dc.subject.keywordAuthorOvalbumin-
dc.subject.keywordAuthorRed ginseng fermented-
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