Oral administration of fermented red ginseng suppressed ovalbumin-induced allergic responses in female BALB/c mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun-Ju | - |
dc.contributor.author | Song, Min-Ji | - |
dc.contributor.author | Kwon, Hye-Soon | - |
dc.contributor.author | Ji, Geun Eog | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.date.available | 2021-02-22T12:46:01Z | - |
dc.date.issued | 2012-07-15 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.issn | 1618-095X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11864 | - |
dc.description.abstract | Anti-allergic efficacy of red ginseng (RG) and fermented red ginseng (FRG) was evaluated. RG or FRG were administered to ovalbumin (OVA)-sensitized mice for 8 weeks. Immunoglobulins (Igs), Th1/Th2 type cytokines, and P-lactoglobulin (BLG) in serum, and intestinal barrier-related molecules in jejunum were measured using enzyme-linked immunosorbent assay or reverse transcription-polymerase chain reaction. Mice sensitized with OVA increased serum IgG(1), IgE, OVA-IgG(1), and OVA-IgE. Both RG and FRG decreased serum IgE, OVA-IgE, and pro-inflammatory cytokines. Serum BLG, a marker of gut permeability, was significantly higher in sensitized animals and was decreased in mice fed RG or FRG. In addition, intestinal barrier-related markers such as MMCP-1, IL-4, TNF-alpha, COX-2, and iNOS mRNA expressions were decreased by RG or FRG. Our results suggest in vivo anti-allergic activities of RG or FRG, which are associated with the regulation of Th1/Th2 balance, intestinal inflammation and subsequent the suppression of IgE. (C) 2012 Elsevier GmbH. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER GMBH | - |
dc.title | Oral administration of fermented red ginseng suppressed ovalbumin-induced allergic responses in female BALB/c mice | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1016/j.phymed.2012.04.008 | - |
dc.identifier.scopusid | 2-s2.0-84864402638 | - |
dc.identifier.wosid | 000309640600007 | - |
dc.identifier.bibliographicCitation | PHYTOMEDICINE, v.19, no.10, pp 896 - 903 | - |
dc.citation.title | PHYTOMEDICINE | - |
dc.citation.volume | 19 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 896 | - |
dc.citation.endPage | 903 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | INTESTINAL PERMEABILITY | - |
dc.subject.keywordPlus | ANTIALLERGIC ACTIVITY | - |
dc.subject.keywordPlus | FOOD ALLERGY | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordAuthor | Food allergy | - |
dc.subject.keywordAuthor | Gut permeability | - |
dc.subject.keywordAuthor | IgE | - |
dc.subject.keywordAuthor | Ovalbumin | - |
dc.subject.keywordAuthor | Red ginseng fermented | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.