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Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice

Authors
Park, Mi-YoungJi, Geun EogSung, Mi-Kyung
Issue Date
Feb-2012
Publisher
SPRINGER
Keywords
Ulcerative colitis (UC); Kaempferol; Dextran sulfate sodium (DSS); Inflammation
Citation
DIGESTIVE DISEASES AND SCIENCES, v.57, no.2, pp.355 - 363
Journal Title
DIGESTIVE DISEASES AND SCIENCES
Volume
57
Number
2
Start Page
355
End Page
363
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/11980
DOI
10.1007/s10620-011-1883-8
ISSN
0163-2116
Abstract
In ulcerative colitis (UC), reduction of inflammation may represent a key mechanism in UC therapy, and anti-inflammatory agents would be good candidates for preventing UC. Kaempferol, a natural flavonoid, is believed to have anti-inflammatory activities and has been shown to be potentially immune-modulatory. The aim of this study was to determine whether kaempferol alleviates the inflammatory responses of dextran sulfate sodium (DSS)-induced colitis in mice. Female C57BL/6J mice were divided into six groups: a negative control group, a DSS control group, and DSS + 0.1% or 0.3% kaempferol pre- or post-fed groups. At the end of the experimental period, clinical and biochemical markers were evaluated. Plasma levels of NO and PGE(2) were significantly decreased in both the 0.3% kaempferol pre- and post-fed groups. The plasma LTB4 level was profoundly decreased in all animals fed kaempferol. Colonic mucosa MPO activity was also suppressed in both the 0.3% kaempferol pre- or post-fed groups. TFF3 mRNA, a marker for goblet cell function, was up-regulated in kaempferol pre-fed animals. These results indicate that kaempferol is an effective anti-inflammatory agent that protects colonic mucosa from DSS-induced UC. Dietary kaempferol fed prior to colitis induction was more effective to suppress some of the colitis-associated markers.
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