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Protein expression pattern in response to ionizing radiation in MCF-7 human breast cancer cells

Authors
Jung, SamilLee, SoonduckLee, JayheeLi, ChengpingOhk, Ji-YeonJeong, Hyeon-KyungLee, SeungkyuKim, SangwooChoi, YunyeongKim, SunghakLee, HeungwooLee, Myeong-Sok
Issue Date
Jan-2012
Publisher
SPANDIDOS PUBL LTD
Keywords
breast cancer; ionizing radiation; 2D-PAGE
Citation
ONCOLOGY LETTERS, v.3, no.1, pp 147 - 154
Pages
8
Journal Title
ONCOLOGY LETTERS
Volume
3
Number
1
Start Page
147
End Page
154
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12002
DOI
10.3892/ol.2011.444
ISSN
1792-1074
1792-1082
Abstract
Breast cancer is one of the most common types of cancer in women and is highly treatable by radiotherapy. However, repeated exposure to radiation results in tumor cell resistance. Understanding the molecular mechanisms involved in the response of tumors to gamma-irradiation is important for improving radiotherapy. For this reason, we aimed to identify radiation-responsive genes at the protein level. In the present study, we observed differentially expressed proteins using 2D-PAGE and MALDI-TOF-MS for the global analysis of protein expression patterns in response to ionizing radiation (IR). When the expression patterns of proteins were compared to a control gel, numerous spots were found that differed greatly. Among them, 11 spots were found to be significantly different. One set of proteins (GH2, RGS17, BAK1, CCNH, TSG6, RAD51B, IGFBP1 and CASP14) was upregulated and another set of proteins (C1QRF, PLSCR2 and p34(SEI-1)) was downregulated after exposure to gamma-rays. These proteins are known to be related to cell cycle control, apoptosis, DNA repair, cell proliferation and other signaling pathways.
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