복합운동이 여성노인의 신경영양성인자 및 인지기능에 미치는 영향

Abstract

The purpose of this study was to investigate the effect of combined exercise on neurotrophic factors and cognitive function in elderly women. Twenty seven elderly women volunteered in this study. All subjects were divided into randomly exercise group(n=14) and control group(n=13). The combined exercise program is consist of the aerobic exercise and the resistance exercise composed of 40-70 %HRR, 50-65 minutes a day for 3 days a week during 12 weeks. Through statistical analysis on repeated measured two-way ANOVA and t-test, this study showed following results that serum brain-derived neurotrophic factor(BDNF), insulin-like growth factor-1(IGF-1) and cognitive function were significantly increased after conbined exercise program in exercise group. Forthemore, the mean concentration of serum BDNF and IGF-1 level were significantly higher than that of the controls. Serum vascular endotherial growth factor(VEGF), meanwhile, was no significantly different each group as well as between two groups. These findings indicate that combined exercise was effective in elderly women to enhance cognitive function and biological variables in this regard. In conclusion, combined exercise contribute to inhibition of neuro-cognitive function declined and reduction in the incidence of neurologic disorders.