GxG-Viztool: A program for visualizing gene-gene interactions in genetic association analysis
- Authors
- Kim K.; Kwon M.-S.; Lee S.Y.; Namkung J.; Li M.D.; Park T.
- Issue Date
- Oct-2012
- Keywords
- Gene-gene interaction; Genetic association analysis; Pattern recognition; Visualization
- Citation
- Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012, pp 838 - 843
- Pages
- 6
- Journal Title
- Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
- Start Page
- 838
- End Page
- 843
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12399
- DOI
- 10.1109/BIBMW.2012.6470249
- ISSN
- 0000-0000
- Abstract
- Gene-gene interactions are important factors underlying a common complex trait that is mostly polygenic. While many methods have been proposed to analyze gene-gene interactions in genetic association studies, the interpretation of the identified gene-gene interactions is not straightforward. In order to aid the interpretation of gene-gene interactions, we developed the GxG-Viztool, an executable program for visualizing gene-gene interactions in genetic association analysis. The GxG-Viztool provides an effective way to recognize genotype combinations that enhance/repress a trait and to display polygenic structure of interactions. The GxG-Viztool implements six graphical tools: checkerboard, pairwise checkerboard, forest, funnel, 3D lattice and parallel coordinate plots, which make it effective to recognize certain patterns in gene-gene interactions. It is freely available at http://bibs. snu. ac. kr/GxG-Viz tool. © 2012 IEEE.
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