Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-kappa B and JNK Pathways
- Authors
- Jung, Hyun-Joo; Kim, Su-Jung; Jeon, Woo-Kwang; Kim, Byung-Chul; Ahn, Kisup; Kim, Kyunghoon; Kim, Young-Myeong; Park, Eun-Hee; Lim, Chang-Jin
- Issue Date
- Oct-2011
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- anti-inflammatory; cyclooxygenase-2; matrix metalloproteinase-9; nitric oxide; n-propyl gallate; reactive oxygen species
- Citation
- INFLAMMATION, v.34, no.5, pp 352 - 361
- Pages
- 10
- Journal Title
- INFLAMMATION
- Volume
- 34
- Number
- 5
- Start Page
- 352
- End Page
- 361
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12488
- DOI
- 10.1007/s10753-010-9241-0
- ISSN
- 0360-3997
1573-2576
- Abstract
- The present study aimed to assess anti-inflammatory activity and underlying mechanism of n-propyl gallate, the n-propyl ester of gallic acid. n-Propyl gallate was shown to contain anti-inflammatory activity using two experimental animal models, acetic acid-induced permeability model in mice, and air pouch model in rats. It suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. It was able to diminish reactive oxygen species level elevated in the LPS-stimulated RAW264.7 macrophage cells. It also suppressed gelatinolytic activity of matrix metalloproteinase-9 enhanced in the LPS-stimulated RAW264.7 macrophage cells. It inhibited inhibitory kappa B-alpha degradation and enhanced NF-kappa B promoter activity in the stimulated macrophage cells. It was able to suppress phosphorylation of c-Jun NH(2)-terminal kinase 1/2 (JNK1/2) and activation of c-Jun promoter activity in the stimulated macrophage cells. In brief, n-propyl gallate possesses anti-inflammatory activity via down-regulation of NF-kappa B and JNK pathways.
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