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The Antiangiogenic and Antinociceptive Activities of n-Propyl Gallate
- Authors
- Jung, H-J.; Lim, C-J.
- Issue Date
- Oct-2011
- Publisher
- WILEY
- Keywords
- n-propyl gallate; antiangiogenic; endostatin; antinociceptive; chorioallantoic membrane
- Citation
- PHYTOTHERAPY RESEARCH, v.25, no.10, pp 1570 - 1573
- Pages
- 4
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 25
- Number
- 10
- Start Page
- 1570
- End Page
- 1573
- ISSN
- 0951-418X
1099-1573
- Abstract
- n-Propyl gallate dose-dependently displayed an inhibitory effect on chick chorioallantoic membrane (CAM) angiogenesis. It markedly increased the endostatin level in both isolated CAM tissues and human umbilical vein endothelial cells (HUVECs). n-Propyl gallate was also able to enhance the endostatin mRNA level in HUVECs. Antinociceptive activity of n-propyl gallate was assessed using an acetic acid-induced writhing test in mice. In brief, n-propyl gallate possesses antiangiogenic activity via up-regulation of endostatin. Copyright (C) 2011 John Wiley & Sons, Ltd.
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