Inhibition by wheat sprout (Triticum aestivum) juice of bisphenol A-induced oxidative stress in young women
- Authors
- Yi, Bitna; Kasai, Hiroshi; Lee, Ho-Sun; Kang, Yunkyeong; Park, Jong Y.; Yang, Mihi
- Issue Date
- 18-Sep-2011
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Endocrine disrupting chemicals; Bisphenol A; Sprout of wheat; 8-OHdG; Malondialdehyde; Fertile women
- Citation
- MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v.724, no.1-2, pp 64 - 68
- Pages
- 5
- Journal Title
- MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Volume
- 724
- Number
- 1-2
- Start Page
- 64
- End Page
- 68
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12495
- DOI
- 10.1016/j.mrgentox.2011.06.007
- ISSN
- 1383-5718
1879-3592
- Abstract
- For health of future generation, fertile young women should be monitored for exposure of endocrine disrupting chemicals (EDCs). Among EDCs, bisphenol A (BPA) is suggested to induce reactive oxygen species (ROS) which play an important role in pathologies of female diseases such as endometriosis. On the other hand, previous studies suggested that sprouts of wheat (Triticum aestivum) have antimutagenicity and antioxidant activity. We performed the 2 weeks intervention of wheat sprout juice (100 ml/day) to investigate its effects on BPA-exposure and -oxidative toxicity in young women (N = 14, age = 24.4 +/- 4.0). Geometrical mean of urinary BPA levels was 1.81 (GSTD, 4.34) mu g/g creatinine. We observed that irregular meals significantly increased levels of urinary BPA approximate 3 times (p = 0.03). In addition, we found BPA-induced oxidative stress is correlated with levels of 8-hydroxydeoxyguanosine (8-OHdG) or malondialdehyde (MDA) levels (p = 0.18 or 0.03, respectively). We also observed a continuous reduction of urinary BPA during the wheat sprout intervention (p = 0.02). In summary, our data suggested potential detoxification of wheat sprouts on BPA-toxicity via antioxidative and interference of absorption, distribution, metabolism and excretion (ADME)-mediated mechanisms in young women. (C) 2011 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.