Transduced Tat-Annexin protein suppresses inflammation-associated gene expression in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Sun Hwa | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Back, Su Sun | - |
dc.contributor.author | Hwang, Hyun Sook | - |
dc.contributor.author | Park, Eun Young | - |
dc.contributor.author | Kang, Tae-Cheon | - |
dc.contributor.author | Kwon, Oh-Shin | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.available | 2021-02-22T13:16:51Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12532 | - |
dc.description.abstract | Annexin-1 (ANX1) is an anti-inflammatory protein as well as an important modulator in inflammation. However, the precise action of ANX1 remains unclear. To elucidate the protective effects of ANX1 on lipopolysaccharide (LPS)-induced murine macrophage Raw 264.7 cells, we constructed a cell-permeable Tat-ANX1 protein. The transduced Tat-ANX1 protein markedly inhibited the expression of cyclooxygenase-2, production of prostaglandin E-2, and generation of pro-inflammatory cytokines in the cells. Furthermore, transduced Tat-ANX1 protein caused a significant reduction in the activation of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK). The results indicate that Tat-ANX1 inhibits the production of inflammatory response cytokines and enzymes by blocking NF-kappa B and MAPK. Therefore, Tat-ANX1 protein may be useful as a therapeutic agent against various inflammatory diseases. [BMB reports 2011; 44(7): 484-489] | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Transduced Tat-Annexin protein suppresses inflammation-associated gene expression in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.7.484 | - |
dc.identifier.scopusid | 2-s2.0-79961035071 | - |
dc.identifier.wosid | 000293358300010 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.44, no.7, pp 484 - 489 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 484 | - |
dc.citation.endPage | 489 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001572949 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CU,ZN-SUPEROXIDE DISMUTASE | - |
dc.subject.keywordPlus | EFFICIENTLY PROTECTS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | Protein therapy | - |
dc.subject.keywordAuthor | Tat-ANX1 | - |
dc.identifier.url | http://koreascience.or.kr/article/JAKO201123163432857.page | - |
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