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Inhibitory effects of OD 78 [3-(4-bromo-phenoxy)-4,5-dihydroxybenzoic acid-methyl ester] on the proliferation and migration of TNF-alpha-induced rat aortic smooth muscle cells

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dc.contributor.authorLim, Yong-
dc.contributor.authorTudev, Munkhtsetseg-
dc.contributor.authorPark, Eun-Seok-
dc.contributor.authorKim, Won-Shik-
dc.contributor.authorLim, Il-Ho-
dc.contributor.authorLee, Mi-Yea-
dc.contributor.authorLee, Heesoon-
dc.contributor.authorJung, Jae-Kyung-
dc.contributor.authorHong, Jin-Tae-
dc.contributor.authorYoo, Hwan-Soo-
dc.contributor.authorLee, Myung-Koo-
dc.contributor.authorPyo, Myoung-Yun-
dc.contributor.authorYun, Yeo-Pyo-
dc.date.available2021-02-22T13:17:02Z-
dc.date.issued2011-07-
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12550-
dc.description.abstractThe proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in the formation and progression of intimal thickening in early-phase atherosclerosis and in restenosis after vascular injury. Tumor necrosis factor-alpha (TNF-alpha) is released from macrophages in atherosclerotic lesions and from neointimal vascular smooth muscle cells after balloon-injury. Obovatol, a major biphenolic component isolated from the Magnolia obovata leaf, is known to have anti-inflammatory and antitumor activities. The goal of this study was to examine the cardioprotective effects of the obovatol derivative OD 78 on the TNF-alpha-induced proliferation and migration of rat aortic smooth muscle cells (RASMCs). The antiproliferative effects of OD 78 on RASMCs were examined by cell counting and [(3)H]-thymidine incorporation assays. Treatment of cells with 1-4 mu M OD 78 inhibited the proliferation and DNA synthesis of TNF-alpha-stimulated RASMCs in a concentration-dependent manner, without cytotoxicity. Treatment with OD 78 inhibited TNF-alpha-mediated p38 phosphorylation, but did not change the activation of extracellular signal-regulated kinase or c-Jun N-terminal kinase. Furthermore, treatment with OD 78 decreased TNF-alpha-induced levels of cyclin E, cyclin D1, CDK2, proliferating cell nuclear antigen, and phosphorylated retinoblastoma protein, but not the CDK4 expression level. Also, OD 78 inhibits the migration of TNF-alpha-induced RASMC in transwells. OD 78 treatment strongly decreased matrix metalloproteinase-9 (MMP-9) expression in a dose-dependent manner, but the MMP-2 expression was unchanged. These results show that OD 78 may be developed as a potential antiproliferative agent for the treatment of angioplasty restenosis and atherosclerosis.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.titleInhibitory effects of OD 78 [3-(4-bromo-phenoxy)-4,5-dihydroxybenzoic acid-methyl ester] on the proliferation and migration of TNF-alpha-induced rat aortic smooth muscle cells-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.1007/s12272-011-0718-7-
dc.identifier.scopusid2-s2.0-80052311252-
dc.identifier.wosid000293460700020-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.34, no.7, pp 1191 - 1199-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume34-
dc.citation.number7-
dc.citation.startPage1191-
dc.citation.endPage1199-
dc.type.docTypeArticle-
dc.identifier.kciidART001573271-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusNECROSIS-FACTOR-ALPHA-
dc.subject.keywordPlusCYCLIN-DEPENDENT KINASES-
dc.subject.keywordPlusMATRIX-METALLOPROTEINASE-9 EXPRESSION-
dc.subject.keywordPlusRETINOBLASTOMA PROTEIN-
dc.subject.keywordPlusBALLOON ANGIOPLASTY-
dc.subject.keywordPlusCORONARY-ARTERIES-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusINJURY-
dc.subject.keywordPlusATHEROSCLEROSIS-
dc.subject.keywordAuthorRat aortic smooth muscle cell-
dc.subject.keywordAuthorTNF-alpha-
dc.subject.keywordAuthorMigration-
dc.subject.keywordAuthorp38-
dc.subject.keywordAuthorMMP-9-
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