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Inhibition of nitric oxide production in RAW 264.7 macrophages by diterpenoids from Phellinus pini

Authors
Jang, Hyun JinYang, Ki-Sook
Issue Date
Jun-2011
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
8,14-labdadien-13-ol; Dehydroabietic acid; Phellinus pini; LPS-activated RAW 264.7 cells
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.34, no.6, pp.913 - 917
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
34
Number
6
Start Page
913
End Page
917
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12565
DOI
10.1007/s12272-011-0608-z
ISSN
0253-6269
Abstract
8,14-labdadien-13-ol (1) and dehydroabietic acid (2) were isolated from the fruit body of Phellinus pini. Elucidation of their structures was based on spectroscopic methods including IR, MS, and NMR (1D and 2D). Two compounds were screened for their ability to inhibit NO production in LPS-activated RAW 264.7 cells. Compounds 1 and 2 at 30 mu M and 50 mu M, respectively, inhibited NO production in activated macrophages.
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