Increase in CIP2A expression is associated with doxorubicin resistance
- Authors
- Choi, Yeon A.; Park, Jeong Su; Park, Mi Young; Oh, Ki Sook; Lee, Myung Sok; Lim, Jong-Seok; Kim, Keun Il; Kim, Kun-yong; Kwon, Junhye; Yoon, Do Young; Moon, Eun-Yi; Yang, Young
- Issue Date
- Mar-2011
- Publisher
- WILEY
- Keywords
- Cancerous inhibitor of PP2A; Doxorubicin; Akt; p53
- Citation
- FEBS LETTERS, v.585, no.5, pp 755 - 760
- Pages
- 6
- Journal Title
- FEBS LETTERS
- Volume
- 585
- Number
- 5
- Start Page
- 755
- End Page
- 760
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12623
- DOI
- 10.1016/j.febslet.2011.01.018
- ISSN
- 0014-5793
1873-3468
- Abstract
- The cancerous inhibitor of protein phosphatase 2A (CIP2A) increases the migration and metastasis of various cancer cells. Overexpression of CIP2A has been shown to increase the proliferation of MDA-MB-231 cells. We thus assessed whether CIP2A expression is associated with sensitivity to doxorubicin. MDA-MB-231 cells showed an increase in CIP2A expression after treatment with doxorubicin, while MCF-7 cells showed a decrease in CIP2A expression. The overexpression of CIP2A in MCF-7 cells overcame the inhibition of cell proliferation in response to doxorubicin treatment. CIP2A expression was not affected by wild-type or mutant p53. However, mutant p53 blocked doxorubicin-mediated CIP2A down-regulation in HCT116 cells. As a regulation mechanism of doxorubicin-mediated CIP2A expression, we showed that phosphorylated Akt was involved in the suppression of CIP2A expression. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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