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beta-Glycerophosphate accelerates RANKL-induced osteoclast formation in the presence of ascorbic acid

Authors
Noh, A. Long Sae MiYim, Mijung
Issue Date
Mar-2011
Publisher
GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
Citation
PHARMAZIE, v.66, no.3, pp 195 - 200
Pages
6
Journal Title
PHARMAZIE
Volume
66
Number
3
Start Page
195
End Page
200
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/12638
DOI
10.1691/ph.2011.0779
ISSN
0031-7144
Abstract
Despite numerous reports of the synergistic effects of beta-glycerophosphate and ascorbic acid in inducing the differentiation of osteoblasts, little is known about their roles in osteoclastic differentiation. Therefore, we investigated the effect of beta-glycerophosphate on osteoclastogenesis in the presence of ascorbic acid using primary mouse bone marrow cultures treated with macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor (NF)-kappa B ligand (RANKL). p-Glycerophosphate dose-dependently increased RANKL-induced osteoclast formation in the presence of ascorbic acid. This stimulatory effect was apparent when beta-glycerophosphate and ascorbic acid were only added during the late stages of the culture period, indicating that they influence later events in osteoclastic differentiation. While the combination of beta-glycerophosphate and ascorbic acid inhibited RANKL-stimulated activation of ERK and p38, and degradation of I kappa B, it increased the induction of c-Fos and NFATc1. In addition, beta-glycerophosphate and ascorbic acid together enhanced the induction of COX-2 following RANKL stimulation. Taken together, our data suggest that beta-glycerophosphate and ascorbic acid have synergistic effects on osteoclast formation, increasing RANKL-mediated induction of c-Fos, NFATc1 and COX-2 in osteoclast precursors.
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