Detailed Information
Cited 0 time in 
Cited 3 time in 
Cited 3 time in
Metadata Downloads
Conditions for the differentiation of melanocyte-precursor cells from human cord blood-derived mesenchymal stem cells
- Issue Date
- Sep-2010
- Publisher
- ACADEMIC JOURNALS
- Keywords
- mesenchymal stem cells; melanocyte-precursor cells; forskolin; microphthalmia-associated transcription factor-M; tyrosinase-related protein-1
- Citation
- AFRICAN JOURNAL OF BIOTECHNOLOGY, v.9, no.36, pp 5975 - 5977
- Pages
- 3
- Journal Title
- AFRICAN JOURNAL OF BIOTECHNOLOGY
- Volume
- 9
- Number
- 36
- Start Page
- 5975
- End Page
- 5977
- ISSN
- 1684-5315
- Abstract
- The loss of skin pigmentation can induce compromised cutaneous immunity, which can result in conditions such as vitiligo. In this study, we evaluated various agents that are able to induce the differentiation of stem cells into melanocytes. We found that a mixture of forskolin (FK), stem cell factor (SCF) and endothelin-3 (EDN-3) induced melanocyte-like morphology in human cord blood-derived mesenchymal stem cells (CB-MSCs). In addition, significant expression of microphthalmia-associated transcription factor-M and tyrosinase-related protein-1 genes was observed. These results suggest that a mixture of FK, SCF and EDN-3 induces the differentiation of melanocyte-precursor cells (MPCs) from CB-MSCs.
- Files in This Item
- Go to Link
- Appears in
Collections - 원격대학원 > 향장미용전공 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.