Detailed Information

Cited 0 time in webofscience Cited 7 time in scopus
Metadata Downloads

Global analysis of microarray data reveals intrinsic properties in gene expression and tissue selectivity

Authors
Kim, ChangsikChoi, JiwonPark, HyunjinPark, YunsunPark, JungsunPark, TaesungCho, KwanghuiYang, YoungYoon, Sukjoon
Issue Date
Jul-2010
Publisher
OXFORD UNIV PRESS
Citation
BIOINFORMATICS, v.26, no.14, pp.1723 - 1730
Journal Title
BIOINFORMATICS
Volume
26
Number
14
Start Page
1723
End Page
1730
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13168
DOI
10.1093/bioinformatics/btq279
ISSN
1367-4803
Abstract
Motivation: It is expected that individual genes have intrinsically different variability in the global expressional trend among them. Thus, the consideration of gene-specific expressional properties will help us to distinguish target-selective gene expression over non-selective over-expression. Results: The re-standardization and integration of heterogeneous microarray datasets, available from public databases, have enabled us to determine the global expression properties of individual genes across a wide variety of experimental conditions and samples. The global averages and SDs of expression for each gene in the integrated microarray datasets were found to be intrinsic properties, which were consistent among independent collections of datasets using different microarray platforms. Using the gene-specific intrinsic parameters to rescale the microarray data, we were able to distinguish novel selective gene expression [cartilage oligomeric matrix protein (COMP) and Collagen X] in breast cancer tissues from non-selective over-expression, a difference that has not been detectable by conventional methods.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yoon, Suk Joon photo

Yoon, Suk Joon
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE