Detailed Information
Cited 0 time in 
Cited 119 time in 
Cited 119 time in
Metadata Downloads
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
- Authors
- Lee, Jason S.; Kim, Yunho; Kim, Ik Soo; Kim, Bogyou; Choi, Hee June; Lee, Ji Min; Shin, Hi-Jai R.; Kim, Jung Hwa; Kim, Ji-Young; Seo, Sang-Beom; Lee, Ho; Binda, Olivier; Gozani, Or; Semenza, Gregg L.; Kim, Minhyung; Kim, Keun Il; Hwang, Daehee; Baek, Sung Hee
- Issue Date
- Jul-2010
- Publisher
- CELL PRESS
- Keywords
- DNA; Humdisease; Proteins
- Citation
- MOLECULAR CELL, v.39, no.1, pp 71 - 85
- Pages
- 15
- Journal Title
- MOLECULAR CELL
- Volume
- 39
- Number
- 1
- Start Page
- 71
- End Page
- 85
- ISSN
- 1097-2765
1097-4164
- Abstract
- Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 이과대학 > 생명시스템학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.