A(3) Adenosine Receptor Antagonist, Truncated Thio-Cl-IB-MECA, Induces Apoptosis in T24 Human Bladder Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Heejong | - |
dc.contributor.author | Kang, Jeong Woo | - |
dc.contributor.author | Lee, Sojung | - |
dc.contributor.author | Choi, Won Jun | - |
dc.contributor.author | Jeong, Lak Shin | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Yoon, Do Young | - |
dc.date.available | 2021-02-22T13:47:37Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.issn | 1791-7530 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13179 | - |
dc.description.abstract | Background: Human A(3) adenosine receptor (A(3)AR) plays an essential role in several plzysiopathological processes. Thus far, A(3)AR-selective ligands have been evaluated as anti-inflammation and anticancer therapeutic agents. Among these ligands, truncated thio-Cl-IB-MECA is a newly reported antagonist, and its function has not been studied. Materials and Methods: Cell viability was measured by MTS assay. Cell cycle progression was analysed by propidium iodide (PI) flow cytometric assay. The apoptotic effects were investigated by Hoechst staining and annexin V-FITC/PI staining. The signal-transduction mechanism was explored by Western blot. Results: Truncated thio-Cl-IB-MECA induced the growth arrest of T24 cells at sub-G(1) phase and provoked apoptosis but not necrosis. Apoptotic death was mediated by the activation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). Conclusion: Since truncated thio-Cl-IB-MECA induces anti-proliferation and apoptotic effects via ERK and JNK activation, it may function as an anticancer agent in human bladder cancer cells. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.title | A(3) Adenosine Receptor Antagonist, Truncated Thio-Cl-IB-MECA, Induces Apoptosis in T24 Human Bladder Cancer Cells | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.scopusid | 2-s2.0-77955819668 | - |
dc.identifier.wosid | 000280796400047 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.30, no.7, pp 2823 - 2830 | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 30 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2823 | - |
dc.citation.endPage | 2830 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TUMOR-GROWTH INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | AGONISTS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | HL-60 | - |
dc.subject.keywordPlus | ERK | - |
dc.subject.keywordPlus | D-4'-THIOADENOSINE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | A3 adenosine receptor | - |
dc.subject.keywordAuthor | A3AR antagonist | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Truncated thio-Cl-IB-MECA | - |
dc.identifier.url | https://ar.iiarjournals.org/content/30/7/2823.short | - |
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