Melanogenesis Inhibitory Effect of Fatty Acid Alkyl Esters Isolated from Oxalis triangularis
- Authors
- Huh, Sungran; Kim, Young-Soo; Jung, Eunsun; Lim, Jihee; Jung, Kwang Sun; Kim, Myeong-Ok; Lee, Jongsung; Park, Deokhoon
- Issue Date
- Jul-2010
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Oxalis triangularis; melanogenesis; fatty acid alkyl ester
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.7, pp 1242 - 1245
- Pages
- 4
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 33
- Number
- 7
- Start Page
- 1242
- End Page
- 1245
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13182
- DOI
- 10.1248/bpb.33.1242
- ISSN
- 0918-6158
1347-5215
- Abstract
- Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.
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