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Melanogenesis Inhibitory Effect of Fatty Acid Alkyl Esters Isolated from Oxalis triangularis

Authors
Huh, SungranKim, Young-SooJung, EunsunLim, JiheeJung, Kwang SunKim, Myeong-OkLee, JongsungPark, Deokhoon
Issue Date
Jul-2010
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
Oxalis triangularis; melanogenesis; fatty acid alkyl ester
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.7, pp 1242 - 1245
Pages
4
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
33
Number
7
Start Page
1242
End Page
1245
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13182
DOI
10.1248/bpb.33.1242
ISSN
0918-6158
1347-5215
Abstract
Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.
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