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The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer

Authors
Jung, SamilJeong, DongjunKim, JinsunYi, LishaKoo, KeunhoeLee, JaehyoukLee, Soon-DuckPark, Jin-WhaChang, BoogiKim, Chang-HwanKim, Chang-JinLee, Myeong-Sok
Issue Date
Jun-2010
Publisher
SPANDIDOS PUBL LTD
Keywords
epigenetics; mcthylation biomarker; cervical cancer; hLHX6-HMR
Citation
ONCOLOGY REPORTS, v.23, no.6, pp.1675 - 1682
Journal Title
ONCOLOGY REPORTS
Volume
23
Number
6
Start Page
1675
End Page
1682
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13199
DOI
10.3892/or_00000811
ISSN
1021-335X
Abstract
The homo sapiens LIM homeobox domain LHX6 gene, hLHX6, is a putative transcription regulator with homeodomain. Multiple cytosine guanine dinucleotides (CpG island) are found in the genomic sequences between exon 4a and exon 5 of the gene encoding hLHX6s (alternative short isoform of hLHX6 gene). This specific CpG island, hLHX6-HMR, is found frequently hypermethylated in 7 cervical cancer cell lines as shown in MSP, BSP, and COBRA assays. Methylation densities were also investigated with human tissue 'samples with a distinctive degree of malignant transformation. Our data showed that the hLHX6-HMR was rarely or partly methylated in the normal and CIN I cells, respectively. In contrast, it was frequently hypermethylated in CIN II, CIN III, and invasive carcinoma cells. In summary, this methylation study led to two conclusions. First, hLHX6-HMR hypermethylation is exclusively associated with cervical carcinogenesis. Second, the epigenetic change in hLHX6-HMR seems to start at CIN I, relatively early stage of cervical cancer development. Therefore, hLHX6-HMR can be used as an effective and sensitive methylation biomarker for early diagnosis of cervical cancer.
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