The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer
DC Field | Value | Language |
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dc.contributor.author | Jung, Samil | - |
dc.contributor.author | Jeong, Dongjun | - |
dc.contributor.author | Kim, Jinsun | - |
dc.contributor.author | Yi, Lisha | - |
dc.contributor.author | Koo, Keunhoe | - |
dc.contributor.author | Lee, Jaehyouk | - |
dc.contributor.author | Lee, Soon-Duck | - |
dc.contributor.author | Park, Jin-Wha | - |
dc.contributor.author | Chang, Boogi | - |
dc.contributor.author | Kim, Chang-Hwan | - |
dc.contributor.author | Kim, Chang-Jin | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.available | 2021-02-22T13:47:50Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.issn | 1791-2431 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13199 | - |
dc.description.abstract | The homo sapiens LIM homeobox domain LHX6 gene, hLHX6, is a putative transcription regulator with homeodomain. Multiple cytosine guanine dinucleotides (CpG island) are found in the genomic sequences between exon 4a and exon 5 of the gene encoding hLHX6s (alternative short isoform of hLHX6 gene). This specific CpG island, hLHX6-HMR, is found frequently hypermethylated in 7 cervical cancer cell lines as shown in MSP, BSP, and COBRA assays. Methylation densities were also investigated with human tissue 'samples with a distinctive degree of malignant transformation. Our data showed that the hLHX6-HMR was rarely or partly methylated in the normal and CIN I cells, respectively. In contrast, it was frequently hypermethylated in CIN II, CIN III, and invasive carcinoma cells. In summary, this methylation study led to two conclusions. First, hLHX6-HMR hypermethylation is exclusively associated with cervical carcinogenesis. Second, the epigenetic change in hLHX6-HMR seems to start at CIN I, relatively early stage of cervical cancer development. Therefore, hLHX6-HMR can be used as an effective and sensitive methylation biomarker for early diagnosis of cervical cancer. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/or_00000811 | - |
dc.identifier.scopusid | 2-s2.0-77951729708 | - |
dc.identifier.wosid | 000277526800025 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.23, no.6, pp 1675 - 1682 | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1675 | - |
dc.citation.endPage | 1682 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | HUMAN-PAPILLOMAVIRUS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NEOPLASIA | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | mcthylation biomarker | - |
dc.subject.keywordAuthor | cervical cancer | - |
dc.subject.keywordAuthor | hLHX6-HMR | - |
dc.identifier.url | https://www.spandidos-publications.com/or/23/6/1675 | - |
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