Suppression of Inducible Nitric Oxide Synthase Expression by Furfuran Lignans from Flower Buds of Magnolia fargesii in BV-2 Microglial Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji Sun | - |
dc.contributor.author | Kim, Jae Yeon | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Lim, Hyo Jin | - |
dc.contributor.author | Lee, Da Yeon | - |
dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T13:48:04Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.issn | 1099-1573 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13216 | - |
dc.description.abstract | Activated microglia produces diverse neurotoxic factors such as nitric oxide (NO) and tumor necrosis factor-a that serve as apoptotic inducers resulting in various neurodegenerative diseases. The inhibition of microgliaderived NO production by inducible nitric oxide synthase (iNOS) has been reported to be beneficial in retarding neurodegenerative disorders. Three active lignans have been isolated from the flower buds of Magnolia fargesii by the bioassay-guided fractionation using lipopolysaccharide (LPS)-activated BV-2 microglial cell culture system. The structures of them were identified as kobusin (1), aschantin (2) and fargesin (3) by the analyses of spectroscopic data. They inhibited the production of NO by activated microglia. Their IC50 values were 21.8 +/- 3.7, 14.8 +/- 2.5 and 10.4 +/- 2.8 Ltg/mL, respectively. They suppressed LPS-induced NF-kappa B activation and the expression of iNOS protein and mRNA. Furthermore, they showed scavenging activity of neurotoxic peroxynitrite that can be produced by NO and superoxide anion. These results imply that lignans from Magnolia fargesii might be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Copyright (C) 2009 John Wiley & Sons, Ltd. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Suppression of Inducible Nitric Oxide Synthase Expression by Furfuran Lignans from Flower Buds of Magnolia fargesii in BV-2 Microglial Cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ptr.3028 | - |
dc.identifier.scopusid | 2-s2.0-77952065006 | - |
dc.identifier.wosid | 000277961600019 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.24, no.5, pp 748 - 753 | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 24 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 748 | - |
dc.citation.endPage | 753 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PEROXYNITRITE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INFARCTION | - |
dc.subject.keywordPlus | HONOKIOL | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | nitric oxide synthase | - |
dc.subject.keywordAuthor | Magnolia fargesii | - |
dc.subject.keywordAuthor | microglia | - |
dc.subject.keywordAuthor | peroxynitrite | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.